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Teclistamab has a clear advantage because it was the first bispecific antibody to be approved, said Adams. Route of administration, the pace of the step-up dosing, the relationship with community providers and risk evaluation and mitigation strategies (REMS) requirements all factor into formulary decisions, she said. Payers may start preferring one bispecific antibody over another because the efficacy among them is similar, Adams said.

Bispecific antibodies are currently approved as late-line therapy, but they are moving up to earlier lines “as they prove their worth, so to speak,” said Adams. She discussed the efficacy, route of administration, dosing mechanism of action, and the various tradeoffs among the four bispecific antibodies that the FDA has approved: teclistamab, elranatamab, talquetamab and linvoseltamab.

In this episode, Optimizing Immunotherapy Selection and Safety Management in NSCLC, the panelists explore the following questions: How are you deciding between available immunotherapies in NSCLC, both as monotherapies and in combination with chemotherapy? What are your current protocols for monitoring and managing adverse events associated with immunotherapies? Does the consistent adverse event profile with cemiplimab plus chemotherapy over 5 years increase this regimen’s clinical value?

Multiple myeloma accounts for only 1.8% of cancers, but it is the second-most common blood cancer, with approximately 36,000 new cases diagnosed each year in the U.S., says Adams. The number of treatment choices has proliferated as new innovative therapies, such as the bispecific antibodies and chimeric antigen receptor (CAR) T-cell therapy, have been developed.

This episode, titled Interpreting EMPOWER-Lung 3: Key Endpoints and Confidence in Cemiplimab-Based Therapy, features lung cancer experts answering the following critical questions: What are your main takeaways from the data covered? Which of the endpoints examined are most important for your clinical practice and why? Does the consistent benefit with cemiplimab plus chemotherapy across the different subgroups increase your confidence?