Videos

Dana-Farber’s Katherine Janeway, M.D., discusses how molecular biomarkers inform treatment decisions in children and adolescents with the bone cancers Ewing sarcoma and osteosarcoma.

Bispecific antibodies are a major advance in multiple myeloma treatment with outstanding efficacy, with many clinical trials underway that are providing the evidence for using them in earlier lines of treatments.

Health systems and clinics need to work together to manage care of the potentially dangerous side effects of bispecific antibodies during the early, step-up phase of treatment, Adams said. Those side effects include cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome.

In ‘A Milestone in Vitiligo: Clinical Efficacy and Long-Term Repigmentation Trends,’ the expert dermatologist examined the following critical questions:

Adams said she has seen firsthand the difference that bispecific antibodies have made. “Patients that would have never gotten into remission are getting into remission. Patients that would have never seen the birth of their grandchild are now seeing the birth of their grandchild,” Adams said. Some real-world data are showing slightly reduced efficacy that was seen in clinical trials, Adams said. There is a need for research that would develop comparator data to other therapies, she noted.

LINKER-MM4 is an open-label study of linvoseltamab as monotherapy in patients who have been newly diagnosed with multiple myeloma. Adams said the results are showing “outstanding efficacy” of 95% that may be due to patients having healthier T cells while still in early-stage treatment.

GLP-1 medications, especially for diabetes, will remain an influential cost driver in drug spending this year, supported by broader prescriber adoption and patient demand.

In this episode, ‘Psychosocial Impacts and Traditional Treatment Modalities in Vitiligo,’ the expert dermatologist explored the following questions:

Self-insured employers and other payers are the startup's customers, but Aradigm CEO and co-founder Will Shrank says the company is looking to bridge the gaps among all stakeholders in burgeoning cell and gene therapy category.

Shrank, a longtime member of the MHE editorial advisory board, discusses the mainstreaming of CAR-T therapy and still-unique aspects of gene therapy

Shrank is president and co-founder of cell and gene therapy (CGT) startup Aradigm, which is working with patients, payers, providers, and manufacturers to manage the cost and financial risk of expensive cell and gene therapy.

Bispecific antibodies could mean simpler regimens that will require fewer clinic visits, Adams said. She also mentioned the possibility of fixed-duration therapy and patients getting to the status of minimal residual disease negative faster.

After step-up dosing, treatment with bispecific antibodies does not require the use of steroids, Adams noted, so patients are spared steroid side effects. Bispecific antibody treatment advances could also mean avoiding proteasome inhibitors, which cause neuropathy, she said.

In this episode titled, ‘Understanding the Pathogenesis and Epidemiology of Vitiligo’, David Rosmarin led the conversation about the following questions:

Updated FDA labeling and NCCN recommendations are pushing more health systems and payers to adopt DPYD testing before fluoropyrimidine treatment to help reduce serious toxicities in cancer care.

New ADA 2026 guidance expands CGM beyond insulin, boosting A1C, time-in-range and cutting costs—tips for patients, providers, payers.

Bispecific antibodies, like other treatments initially approved for later lines of therapy, are moving "upstream" in multiple myeloma treatment, Adams said. She discussed the MajesTEC-3 trial that led to the approval of teclistamab plus daratumumab as second-line therapy, the IMMUNOPLANT trial of linvoseltamab, and the MajesTEC-7 trial comparing a combination of teclistamab, daratumumab and lenalidomide with a combination of talquetamab, daratumumab and lenalidomide.

National Comprehensive Cancer Network (NCCN) guidelines have limited influence on multiple myeloma treatment and its sequencing because treatment is evolving so quickly, Adams said. “Therapies are coming out left and right faster than we can keep up with, and it’s faster than the NCCN can keep up with as well,” she said.

Higher CGM use links to bigger A1c drops in type 2 diabetes, revealing how monitoring and meds like GLP-1s drive better control.

In the final episode, Shaping the Future of Immunotherapy in NSCLC, the panelists explore the following critical questions: Which additional data would you like to see with immunotherapies used in NSCLC? What is the relevance of the EMPOWER-Lung 3 for patients and payors? How do you see the future management of NSCLC evolving with immunotherapies and do you see a potential role for extended dosing?

This episode, titled Future Directions in Vitiligo: Emerging Therapies and Patient-Centered Care, features Dr. Desai discussing the following critical questions:

A pharmacist-led specialty pharmacy model that expands into care management services could help health systems improve chronic disease outcomes while supporting cost savings under value-based care, according to presenters at the Asembia Specialty Pharmacy Summit that took place in Las Vegas this week.

HealthDyne is one of the dispensing pharmacies for the Lilly Employer Direct program that the company launched in March. HealthDyne executives expect their skyrocketing growth in its new direct-to-employer business.

HealthDyne’s Sarah Thomas and David Skomo say that direct-to-patient arrangements eliminate opacity in drug pricing and allow employers to offer drug coverage with a certainty about the budget required.

Even for high-priced specialty drugs, direct-to-patient (DTP) sales could help with access and affordability, say HealthDyne’s David Skomo and Sarah Thomas. Payers can lower out-of-pocket costs for members by funding health reimbursement arrangements, money that can be used to buy DTP drugs.

A high-touch specialty pharmacy program that combines pharmacist support, telehealth and value-based care reduced medical costs and improved outcomes for patients with diabetes, according to presenters at the Asembia Specialty Pharmacy Summit.

Teclistamab has a clear advantage because it was the first bispecific antibody to be approved, said Adams. Route of administration, the pace of the step-up dosing, the relationship with community providers and risk evaluation and mitigation strategies (REMS) requirements all factor into formulary decisions, she said. Payers may start preferring one bispecific antibody over another because the efficacy among them is similar, Adams said.

Frequent CGM use ties to bigger A1c drops in type 2 diabetes, even across GLP-1, SGLT2, and insulin regimens.