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K-Cast: Optimizing Narcolepsy Care

Opinion|Videos|October 16, 2025

Exploring Secondary Treatment Options for Metastatic ER+/HER2- Breast Cancer

Author(s)Daphne Stewart, MD, Kirollos Hanna, PharmD, BCPS, BCOP, FACCC, FAPO

As resistance to endocrine and CDK4/6 inhibitor therapy grows, elacestrant offers a promising targeted option for patients with ESR1 mutations driving treatment failure.

Episodes in this series

EP. 1 Introducing the EMERALD Trial

EP. 1 Introducing the EMERALD Trial

EP. 2 Exploring Secondary Treatment Options for Metastatic ER+/HER2- Breast Cancer

EP. 2 Exploring Secondary Treatment Options for Metastatic ER+/HER2- Breast Cancer

The presentation places the EMERALD trial within the broader treatment context of metastatic ER+/HER2– disease. As resistance to endocrine therapy and CDK4/6 inhibitors grows, second-line options remain limited.

Elacestrant emerged as a potential solution by directly targeting ESR1 mutations, which drive endocrine resistance. The trial findings inform how clinicians may optimize sequencing strategies and enhance patient outcomes through more targeted, mutation-informed care.

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