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K-Cast: Optimizing Narcolepsy Care

Opinion|Videos|October 16, 2025

Introducing the EMERALD Trial

Author(s)Daphne Stewart, MD, Kirollos Hanna, PharmD, BCPS, BCOP, FACCC, FAPO

The EMERALD trial evaluated elacestrant, an oral SERD, as a potential new standard for patients with ER+/HER2– advanced breast cancer resistant to prior endocrine therapies.

Episodes in this series

EP. 1 Introducing the EMERALD Trial

EP. 1 Introducing the EMERALD Trial

EP. 2 Exploring Secondary Treatment Options for Metastatic ER+/HER2- Breast Cancer

EP. 2 Exploring Secondary Treatment Options for Metastatic ER+/HER2- Breast Cancer

The EMERALD trial is a pivotal phase 3 study evaluating elacestrant, an oral selective estrogen receptor degrader, in patients with estrogen receptor-positive, HER2-negative advanced breast cancer.

The trial sought to determine whether elacestrant could offer improved outcomes over standard endocrine therapies. It specifically addressed treatment-resistant cases that had previously received endocrine therapy and CDK4/6 inhibitors, representing a significant unmet clinical need in metastatic breast cancer management.

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