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AMCP Nexus 2025|

2025 Fall Clinical Dermatology|

Between the Lines: Diving Deeper Into the EMERALD Trial

Opinion|Videos|October 30, 2025

Subgroup Analysis of Patients With No Prior Chemotherapy in EMERALD Trial

Author(s)Daphne Stewart, MD, Kirollos Hanna, PharmD, BCPS, BCOP, FACCC, FAPO

Among chemotherapy-naive patients, elacestrant extended median progression-free survival compared with standard therapy, particularly in ESR1-mutated cases.

Episodes in this series

EP. 1 Introducing the EMERALD Trial

EP. 1 Introducing the EMERALD Trial

EP. 2 Exploring Secondary Treatment Options for Metastatic ER+/HER2- Breast Cancer

EP. 2 Exploring Secondary Treatment Options for Metastatic ER+/HER2- Breast Cancer

EP. 3 EMERALD Trial Design and Baseline Characteristics

EP. 3 EMERALD Trial Design and Baseline Characteristics

EP. 4 Key Efficacy and Safety Data from the EMERALD Trial

EP. 4 Key Efficacy and Safety Data from the EMERALD Trial

EP. 5 Subgroup Analysis of Patients With No Prior Chemotherapy in EMERALD Trial

EP. 5 Subgroup Analysis of Patients With No Prior Chemotherapy in EMERALD Trial

EP. 6 Subgroup Analysis From the Phase 3 EMERALD Trial by Prior Duration of Endocrine Therapy Plus CDK4/6 Inhibitor

EP. 6 Subgroup Analysis From the Phase 3 EMERALD Trial by Prior Duration of Endocrine Therapy Plus CDK4/6 Inhibitor

A focused analysis of chemotherapy-naive patients revealed elacestrant’s superior efficacy, demonstrating a median PFS of 3.7 months vs 2.0 months for standard of care in all patients. Among those with ESR1-mutated tumors, elacestrant extended median progression-free survival to 5.3 months vs 1.9 months for standard of care. These findings highlight elacestrant’s particular benefit in patients who have not yet received chemotherapy.

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