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Opinion|Videos|November 13, 2025

Subgroup Analysis of Patients With No Prior Chemotherapy in EMERALD Trial

Among chemotherapy-naive patients, elacestrant extended median progression-free survival compared with standard therapy, particularly in ESR1-mutated cases.

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A focused analysis of chemotherapy-naive patients revealed elacestrant’s superior efficacy, demonstrating a median PFS of 3.7 months vs 2.0 months for standard of care in all patients. Among those with ESR1-mutated tumors, elacestrant extended median progression-free survival to 5.3 months vs 1.9 months for standard of care. These findings highlight elacestrant’s particular benefit in patients who have not yet received chemotherapy.

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