Videos

In this closing segment, Drs. Lovly and Shaw synthesize the most important lessons from the 7-year CROWN update, address the study's remaining limitations and unanswered questions, and reflect on what this data means for the broader landscape of ALK-positive NSCLC care — from treatment guidelines to payer decision-making to patient survivorship.

This segment brings together two essential threads — the broader context of lorlatinib's remarkable durability relative to earlier ALK inhibitors, and the practical, multidisciplinary strategies clinicians need to support patients on long-term therapy — while making a compelling case for why these data are directly relevant to community oncology practice.

Aksharananda (Akshar) Rambachan, M.D., an UCSF physician-researcher, says that when used together, the numeric pain score and function scores give clinicians a far more complete clinical picture of a patient’s pain.