News|Videos|November 18, 2025

Botulinum toxin may directly reduce depression by altering brain activity

Discover how botulinum toxin injections in the glabella affect brain function, enhancing mood by altering emotional feedback from frowning.

According to Mark Nestor, M.D., Ph.D., shared with MHE that injecting botulinum toxin in the glabella changes how the amygdala works and stops the brain from getting feedback from frowning, creating a direct mood-lifting effect that is not related to how a person looks.

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