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Investigator Charles C. Wykoff, M.D., Ph.D., discusses the mechanism of Zenkuda (tarcocimab) and why there is a need for new anti-vascular endothelial growth factor (VEGF) to treat patients with diabetic retinopathy.

Investigator Charles C. Wykoff, M.D., Ph.D., discusses the full results of the GLOW2 study, which found that Zenkuda (tarcocimab) resulted in improvement in diabetic retinopathy, including in patients who were taking GLP-1 agonists for their diabetes.

A study in Advanced Functional Materials found that mRNA vaccine nanoparticles can survive drying and rehydration in microneedle patch material, offering a potential path toward vaccines that no longer require cold chain storage.

Disruption in copay assistance may be one of the reasons.

Real-world results from the ongoing ELARA study found every-four-week Eylea HD produced meaningful BCVA gains with a safety profile consistent with prior aflibercept trials.

Enlicitide, a macrocyclic peptide that binds PCSK9 and blocks LDL receptor interaction, is the first oral PCSK9 inhibitor FDA-approved to lower LDL-C.

Experts agreed that staging and surveillance imaging should be used when there is a 15% risk of metastasis.

Specific brainstem inhibitory neurons help the brain filter out distractions by suppressing competing sensory signals, allowing mice (and presumably humans) to stay focused.

The FTC has settled its antitrust case against Caremark, requiring changes to drug pricing and rebate practices with up to $8.5 billion in potential consumer savings over the next 10 years.

Most favored nation pricing may well deliver lower drug costs in the short term. But the real ledger, measured in research not pursued, diseases not prioritized, and markets left behind, will take years to fully calculate.

Judi Health has also launched two new services: Judi Care for medical benefit administration and Judi Cloud for those who want to license the Judi platform.

Two-thirds of patients had leftover pills, and some used opioids beyond guideline-recommended durations, an FDA-backed study found.

In this conversation, Johns Hopkins researchers describe a newly identified population of brainstem neurons that are crucial for selective attention in mice and may offer fresh insight into ADHD in humans.

University of Michigan researchers found that the experimental DT-109 reduced liver inflammation and MASH severity in nonhuman primates by targeting Clostridium perfringens and restoring gut barrier integrity.

A former radiation oncologist turned chief medical officer, Rex Hoffman, M.D., MBA, has spent the past several years expanding his leadership footprint across Providence Holy Cross Medical Center’s health system while authoring multiple books aimed at helping physicians navigate the transition into executive roles.

Transparency Rising is the new name for Transparency-Rx, a trade group of smaller PBMs challenging the "big 3."

Employers cite broker recommendations, cost-control effectiveness, and long-term costs as top factors shaping GLP-1 coverage decisions, according to a new survey from the International Foundation of Employee Benefit Plans.

Large language models are sure-footed at supplying answers, but what happens in medical contexts when that certainty can be a liability?

As a wave of blockbuster biologics face loss of exclusivity, some hope that there may be a “second phase” of biosimilar adoption.

A new study in JAMA Network Open projects that the number of Medicare beneficiaries 65 and older living with HIV will grow from approximately 122,000 to 194,000 by 2035, driving cumulative Medicare costs of $187.2 billion, with antiretroviral therapy alone accounting for 63% of that spending.

Provider networks are a fundamental part of U.S. health insurance. But an increasing number of self-insured employers are offering low-premium health plans without networks, and the CMS is working toward having such plans available on the ACA marketplaces.

The premiums may be low but the deductibles are high. More people are enrolling in ACA bronze plans because of the expiration of COVID-19 enhanced subsidies. And the Trump administration is taking steps to encourage enrollment in high-deductible, low-premium catastrophic coverage.

Marc Elia of Invyvid explains the difference between vaccines and monoclonal antibodies.

Improving outcomes in chronic conditions will require eliminating friction and creating a connected foundation that supports people continuously.

University of Vermont Health dermatologists argue that is wasteful and causes undue worry to routinely test patients taking isotretinion for elevated liver enzymes and triglycerides.

An American Diabetes Association survey has found that high insulin costs are straining patients financially, with 1 in 3 cutting groceries. A new Senate bill aims to limit copays and boost PBM rebate transparency.

The findings from a matched cohort study add to the body of evidence that people with vitiligo are likely to contend with other health problems.

A phase 3b trial found that Otsuka's centanafadine significantly improved both ADHD symptoms and anxiety symptoms in adults with ADHD and comorbid anxiety, with effects emerging as early as week 1 and holding through 8 weeks, as the drug awaits an FDA decision expected July 24, 2026.