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Opinion|Videos|March 28, 2025

Setting the Stage: Immunotherapy’s Impact and EMPOWER-Lung 1 Study Design

Author(s)Eric K. Singhi, M.D., Ben Creelan, M.D.

Panelists discuss how over the last five years, immunotherapy, particularly PD-1 inhibitors, has revolutionized advanced non-small cell lung cancer (NSCLC) treatment, offering promising first-line therapy options. Prior to the EMPOWER-Lung 1 study, PD-1 inhibitors showed improved survival outcomes as monotherapy. Treatment considerations have since evolved to incorporate patient-specific factors, optimizing therapy based on individual characteristics.

Episodes in this series

2 experts in this video

EP. 1 Setting the Stage: Immunotherapy’s Impact and EMPOWER-Lung 1 Study Design

2 experts in this video

EP. 2 Optimizing First-Line and Sequential Therapy in Advanced NSCLC

2 experts in this video

EP. 3 EMPOWER-Lung 1: Baseline Characteristics and Modern Treatment Considerations in NSCLC

2 experts in this video

EP. 4 Evaluating Five-Year Efficacy Outcomes in EMPOWER-LUNG 1

2 experts in this video

EP. 5 Subgroup Analyses of EMPOWER-LUNG 1

2 experts in this video

EP. 6 Managing Safety and Quality of Life With Cemiplimab in Advanced NSCLC

2 experts in this video

EP. 7 The Role of Continuing Cemiplimab in Second-Line Therapy After Progression

2 experts in this video

EP. 8 Closing Insights: The Future of Cemiplimab in NSCLC and Beyond

EP. 9 Evaluating Five-year Efficacy Outcomes in the EMPOWER-Lung 1 Study | Written Recap

EP. 9 Evaluating Five-year Efficacy Outcomes in the EMPOWER-Lung 1 Study | Written Recap

Video content above is prompted by the following:

Over the last five years, how has the emergence of immunotherapy in advanced NSCLC shifted the treatment paradigm in terms of the use of PD-1 inhibitors as first-line therapy?
Prior to this study, what was known about the survival outcomes of patients receiving PD-1 inhibitors when used as monotherapy in the treatment of advanced NSCLC?
How have treatment considerations changed regarding the characteristics of patients receiving PD-1 inhibitors since the initiation of this trial?

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