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Opinion|Videos|March 28, 2025

Optimizing First-Line and Sequential Therapy in Advanced NSCLC

Author(s)Eric K. Singhi, M.D., Ben Creelan, M.D.

Panelists discuss how biomarkers like PD-L1 guide first-line therapy in advanced non-small cell lung cancer (NSCLC), with higher expression favoring PD-1 inhibitors. Other factors like performance status and comorbidities also support their use. Post progression, PD-1 inhibitors are often used alone or in combination for subsequent lines of treatment.

Episodes in this series

2 experts in this video

EP. 1 Setting the Stage: Immunotherapy’s Impact and EMPOWER-Lung 1 Study Design

2 experts in this video

EP. 2 Optimizing First-Line and Sequential Therapy in Advanced NSCLC

2 experts in this video

EP. 3 EMPOWER-Lung 1: Baseline Characteristics and Modern Treatment Considerations in NSCLC

2 experts in this video

EP. 4 Evaluating Five-Year Efficacy Outcomes in EMPOWER-LUNG 1

2 experts in this video

EP. 5 Subgroup Analyses of EMPOWER-LUNG 1

2 experts in this video

EP. 6 Managing Safety and Quality of Life With Cemiplimab in Advanced NSCLC

2 experts in this video

EP. 7 The Role of Continuing Cemiplimab in Second-Line Therapy After Progression

2 experts in this video

EP. 8 Closing Insights: The Future of Cemiplimab in NSCLC and Beyond

EP. 9 Evaluating Five-year Efficacy Outcomes in the EMPOWER-Lung 1 Study | Written Recap

EP. 9 Evaluating Five-year Efficacy Outcomes in the EMPOWER-Lung 1 Study | Written Recap

Video content above is prompted by the following:

What role do biomarkers like PD-L1 play in determining first-line therapy options for advanced NSCLC, and how does level of expression impact initial drug choice?
What other patient characteristics influence initial treatment choices in advanced NSCLC, and how do they support using PD-1s as first-line options?
Following disease progression on initial therapy, how frequently are PD-1 inhibitors used alone or in combination for subsequent lines of treatment?

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