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Opinion|Videos|April 4, 2025

EMPOWER-Lung 1: Baseline Characteristics and Modern Treatment Considerations in NSCLC

Author(s)Eric K. Singhi, M.D., Ben Creelan, M.D.

Panelists discuss how, at their practices, histology, staging and ECOG performance status guide treatment decisions for advanced non-small cell lung cancer (NSCLC). Compared with EMPOWER-Lung 1, these factors remain crucial. Key biomarkers, such as PD-L1 expression, influence PD-1 inhibitor efficacy. In 2025, treatment options are more personalized with emerging therapies.

Episodes in this series

2 experts in this video

EP. 1 Setting the Stage: Immunotherapy’s Impact and EMPOWER-Lung 1 Study Design

2 experts in this video

EP. 2 Optimizing First-Line and Sequential Therapy in Advanced NSCLC

2 experts in this video

EP. 3 EMPOWER-Lung 1: Baseline Characteristics and Modern Treatment Considerations in NSCLC

2 experts in this video

EP. 4 Evaluating Five-Year Efficacy Outcomes in EMPOWER-LUNG 1

2 experts in this video

EP. 5 Subgroup Analyses of EMPOWER-LUNG 1

2 experts in this video

EP. 6 Managing Safety and Quality of Life With Cemiplimab in Advanced NSCLC

2 experts in this video

EP. 7 The Role of Continuing Cemiplimab in Second-Line Therapy After Progression

2 experts in this video

EP. 8 Closing Insights: The Future of Cemiplimab in NSCLC and Beyond

EP. 9 Evaluating Five-year Efficacy Outcomes in the EMPOWER-Lung 1 Study | Written Recap

EP. 9 Evaluating Five-year Efficacy Outcomes in the EMPOWER-Lung 1 Study | Written Recap

Video content above is prompted by the following:

How does histology, staging and ECOG performance status play into treatment considerations at your practice today, and how do these factors compare to the baseline characteristics of this study?
What other biomarkers, if any, are important in determining the efficacy of PD-1 inhibitors like cemiplimab before initiating therapy, both in NSCLC and for other indications?
Overall, how does this patient population compare with those treated in 2025 with immune checkpoint inhibitors or other first-line treatment options for advanced NSCLC?

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