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Raj Chovatiya Discusses Safety, Efficacy, and Real-World Insights in Post-Approval Studies on Jak Inhibitors | AAD 2024

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At the American Academy of Dermatology meeting in San Diego, Raj J. Chovatiya, M.D., Ph.D, discussed the evolution of studies on Jak inhibitors post-approval.

At the American Academy of Dermatology meeting in San Diego, Raj J. Chovatiya, M.D., Ph.D, discussed the evolution of studies on Jak inhibitors post-approval.

The clinical associate professor at the Rosalind Franklin University Chicago Medical School and founder and director of the Center for Medical Dermatology and Immunology Research in Chicago, shared the importance of long-term extension arms and innovative phase four designs to assess real-world outcomes.

It's notable to share that data from extended phase three studies showed no clear safety signals for box warning events, reassuring concerns raised at the launch.

Ongoing phase four studies are exploring lower Jak inhibitor doses and comparing their use to biologic therapies.

Registries are also providing insights into real-world efficacy and safety, contributing to increased comfort with Jak inhibitors over time.

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