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Opinion|Videos|February 18, 2025

Narcolepsy Treatments

An expert discusses treatments for narcolepsy, comparing options for managing excessive daytime sleepiness (EDS) and cataplexy, and examines the advantages, limitations, and clinical scenarios for medications targeting EDS versus compared with those for both EDS and cataplexy.

Episodes in this series

Video content above is prompted by the following:

  • What are the currently available treatments for narcolepsy, and how do they address different aspects of the condition, such as EDS and cataplexy?
  • What are the comparative advantages and limitations of stimulant medications, wake-promoting agents, and other therapeutic options for managing EDS?
  • How does do efficacy and adverse event profiles of medications specifically targeting EDS (eg, modafinil, armodafinil, solriamfetol, and pitolisant) compare to with those approved for both EDS and cataplexy (eg, sodium oxybate, and low-sodium oxybate)? In what scenarios would one category of medication be preferred over the other in clinical practice?

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