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AMCP Nexus 2025|

2025 Fall Clinical Dermatology|

Between the Lines: Diving Deeper Into the EMERALD Trial

Opinion|Videos|April 3, 2025

LPA1 Modulation: Admilparant’s Role in the Evolution of IPF and PPF Therapies

Author(s)Eric Cannon, PharmD, FAMCP

Eric Cannon, PharmD, FAMCP, discusses how LPA1 receptor activation promotes fibrosis in idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) through myofibroblast differentiation and ECM production. Admilparant shows promising antifibrotic activity in preclinical models but requires phase 3 efficacy data. As a novel targeted therapy, it may complement existing antifibrotics, particularly for progressive phenotypes with high LPA1 expression.

Episodes in this series

EP. 1 Distinguishing Between the Different Interstitial Lung Diseases

EP. 1 Distinguishing Between the Different Interstitial Lung Diseases

EP. 2 Mortality Rates and Comorbidities Associated With Idiopathic Pulmonary Fibrosis and Progressive Pulmonary Fibrosis

EP. 2 Mortality Rates and Comorbidities Associated With Idiopathic Pulmonary Fibrosis and Progressive Pulmonary Fibrosis

EP. 3 Epidemiology and Economic Burden of IPF and PPF

EP. 3 Epidemiology and Economic Burden of IPF and PPF

EP. 4 Best Practices in Diagnosis of IPF and PPF

EP. 4 Best Practices in Diagnosis of IPF and PPF

EP. 5 The Role of Biomarkers and Biopsy for IPF and PPF

EP. 5 The Role of Biomarkers and Biopsy for IPF and PPF

EP. 6 Key Unmet Needs in IPF and PPF

EP. 6 Key Unmet Needs in IPF and PPF

EP. 7 The Role of Corticosteroids in Managing Pulmonary Fibrosis

EP. 7 The Role of Corticosteroids in Managing Pulmonary Fibrosis

EP. 8 Exploring Nintedanib and Pirfenidone for the Treatment of Idiopathic Pulmonary Fibrosis

EP. 8 Exploring Nintedanib and Pirfenidone for the Treatment of Idiopathic Pulmonary Fibrosis

EP. 9 Monitoring for and Managing the Adverse Events Associated With Antifibrotic Agents

EP. 9 Monitoring for and Managing the Adverse Events Associated With Antifibrotic Agents

EP. 10 Nonpharmacological Management Options for Patients With Pulmonary Fibrosis

EP. 10 Nonpharmacological Management Options for Patients With Pulmonary Fibrosis

EP. 11 Guideline Recommendations for the Treatment of Pulmonary Fibrosis

EP. 11 Guideline Recommendations for the Treatment of Pulmonary Fibrosis

EP. 12 Unmet Needs in the Treatment Guidelines for Pulmonary Fibrosis

EP. 12 Unmet Needs in the Treatment Guidelines for Pulmonary Fibrosis

EP. 13 Treatment Algorithms and Insurance Coverage for Pulmonary Fibrosis

EP. 13 Treatment Algorithms and Insurance Coverage for Pulmonary Fibrosis

EP. 14 The Future of Treatment Approaches for Pulmonary Fibrosis

EP. 14 The Future of Treatment Approaches for Pulmonary Fibrosis

EP. 15 Bridging gaps in pulmonary fibrosis management: Insights into diagnosis, treatment and future directions

1 expert in this video

EP. 16 The PDE4B Pathway: Exploring Nerandomilast’s Potential in Pulmonary Fibrosis Treatment

1 expert in this video

EP. 17 LPA1 Modulation: Admilparant’s Role in the Evolution of IPF and PPF Therapies

1 expert in this video

EP. 18 The Future of Pulmonary Fibrosis Management: Precision Medicine, Biomarkers and AI

Video content above is prompted by the following:

What evidence supports the role of LPA1 in modulating fibrotic processes, particularly in IPF and PPF?
What has the data demonstrated with admilparant so far, and what future data is needed for this therapy?
How do you envision admilparant fitting into treatment algorithms for patients with IPF and PPF?

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