Opinion|Videos|March 27, 2025

The PDE4B Pathway: Exploring Nerandomilast’s Potential in Pulmonary Fibrosis Treatment

Eric Cannon, PharmD, FAMCP, discusses how the PDE4B pathway promotes inflammation and fibrosis in idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) by regulating cAMP levels and fibroblast activity. Nerandomilast has shown promising anti-inflammatory and antifibrotic effects in preclinical models, with early clinical trials suggesting good tolerability and potential lung function stabilization. However, larger phase 3 trials with longer follow-up are needed to confirm efficacy, safety and impact on disease progression.

Episodes in this series

Video content above is prompted by the following:

  • What is the significance of the PDE4B pathway in the pathogenesis of IPF and PPF?
  • What has the data demonstrated with nerandomilast so far, and what future data is needed for this therapy?
  • How do you envision nerandomilast fitting into treatment algorithms for patients with IPF and PPF?

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