Exploring Advances and Challenges in Heart Failure with Stephen Greene of Duke Heart Center
In this final part of a two-part video series, Stephen Greene, MD, of Duke University School of Medicine, discussed the definition of worsening heart failure, emphasizing its four key elements: worsening signs and symptoms, chronic established heart failure, breakthrough in background therapy, and urgent escalation of therapy.
He highlighted the shift in clinical trial design, with increasing inclusion of outpatient settings and the use of worsening heart failure as a primary endpoint.
Regarding contextualizing heart failure risk, Greene expressed concern about the persisting lack of therapeutic urgency, comparing the urgency in cancer care to the insufficient attention given to heart failure. Despite effective and well-tolerated therapies, implementation remains low, contributing to avoidable hospitalizations and deaths.
Lastly, on the topic of renaming heart failure to reduce fear, Greene mentioned it’s a very popular discussion in debated circles. However, he cautioned against potential unintended consequences, emphasizing the importance of transparent communication about the condition's seriousness and the hope offered by evidence-based therapies.
Muthu Vaduganathan Gives Insights on the Cost Effectiveness of SGLT2 Inhibitors
March 29th 2024In this second part of a two-part video series, MHE editors spoke with Muthiah “Muthu” Vaduganathan MD, MPH, consultant cardiologist at Brigham and Women's Hospital and a member of faculty at Harvard Medical School, about the cost effectiveness of SGLT2 inhibitors.
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Muthiah “Muthu” Vaduganathan Discusses the Role of SGLT2 Inhibitors in Heart Failure Treatment
March 27th 2024Editors of Managed Healthcare Executive spoke with Muthiah “Muthu” Vaduganathan MD, MPH, consultant cardiologist at Brigham and Women's Hospital and a member of faculty at Harvard Medical School, about the evolving treatment landscape for heart failure, emphasizing the use of SGLT2 inhibitors alongside other foundational therapies.
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Stephen Greene, MD, Gives Insight on the New Heart Failure Drug Sotagliflozin
February 20th 2024Stephen Greene, MD, of Duke University School of Medicine, explains that Inpefa (sotagliflozin), a recently FDA-approved dual SGLT-1 and SGLT-2 inhibitor, aims to reduce cardiovascular death, heart failure, hospitalizations, or urgent heart failure visits among patients with heart failure, chronic kidney disease, type 2 diabetes, and another cardiovascular risk factor.
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