Clinical Insights With Subcutaneous Biologics

They work by inhibiting inflammatory cytokines, but a small percentage of patients may experience “paradoxical psoriasis.”

Merck and Johnson & Johnson have both acquired bispecific antibodies with applications in autoimmune and inflammatory conditions.

Driving this growth will be the approvals of novel biologics, such as gene therapy, RNA-based therapeutics, and antibody-drug conjugates.

Nine of the 10 top specialty drugs by expenditure are biologics, according to the Pharmaceutical Strategies Group report on specialty drug spending.

The number of biologics approved as treatments for psoriasis has proliferated but the FDA has approved just four for use in children. Six biologics for pediatric psoriasis are in various stages of development.

The FDA has required all approved CAR T therapies to have a boxed warning about the risk of secondary malignancies after treatment.