Insulin degludec/insulin aspart (Ryzodeg, Novo Nordisk) administered twice daily, provides successful glycemic control with fewer injections than a basal-bolus regimen, according to data presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria.
Insulin degludec/insulin aspart (Ryzodeg, Novo Nordisk) administered twice daily, provides successful glycemic control with fewer injections than a basal-bolus regimen, according to data presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria.
In the 26-week randomized multinational phase 3b trial, patients previously treated with basal insulin were randomly assigned to a regimen of either twice-daily Ryzodeg, or a basal-bolus regimen of once-daily insulin degludec plus 2 to 4 injections of insulin aspart.
The study did not meet its primary end point of non-inferiority; however, the results showed that HbA1c was reduced for patients on either regimen, to 7.0% and 6.8% respectively, with no significant difference between the 2 regimens.
Patients who received Ryzodeg experienced a numerically lower rate of overall and nocturnal confirmed hypoglycemic episodes, 19% and 20% less, respectively.
The study was designed to investigate 2 different regimens for patients on basal insulin who need mealtime intensification. The results show that Ryzodeg could potentially be a simple alternative to basal-bolus therapy, as it delivers successful reduction in A1C with fewer injections than a basal-bolus regimen.
"Patients currently using basal-bolus regimens may need to take up to 4 daily injections, which can be a great burden and very inconvenient," said Dr Helena Rodbard, the study’s principal investigator and endocrinologist in Rockville, Md., in a press release. "This new treatment offers the potential for a simple alternative to basal-bolus for patients who require intensification of basal insulin regimens.”
Get the latest industry news, event updates, and more from Managed healthcare Executive.
PBM-Offered Genomics Testing Could Reshape Prescribing of Medications
July 25th 2025Two PBMs, True Rx Health Strategies and Capital Rx, are using pharmacogenomics — how a person’s DNA affects their response to medications — to reduce the trial-and-error of prescribing medications, saving employers and patients time and money.
Read More
FDA Extends Review of Blenrep Combinations in Multiple Myeloma
July 24th 2025Last week, an FDA advisory committee against the risk-benefit profile of Blenrep in combination with other therapies. Regulators and reviewers were concerned about the ocular side effects and dosing and tolerability. The new action date is Oct. 23, 2025.
Read More
Sarepta to Pause Shipments of the Gene Therapy Elevidys
July 22nd 2025Sarepta officials said the temporary halt in shipments was done to maintain a productive working relationship with regulators while they address a safety labeling update about the risk of acute liver disease related to Elevidys.
Read More