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Highly resistant strains of both gram-positive and gram-negative bacteria are becoming commonplace in both the inpatient and outpatient setting. Recently developed antimicrobials have targeted resistant gram-positive pathogens, but the problem of resistant gram-negative pathogens remains. Tigecycline (Tygacil, Wyeth) is an injectable antimicrobial and the first in a new class of agents (the glycylcyclines) that possesses activity against key gram-positive and gram-negative bacterial pathogens. Tigecycline overcomes common tetracycline resistance mechanisms and has shown in vitro and in vivo activity against multidrug-resistant organisms. Tigecycline treatment produced clinical and microbiologic outcomes similar to standard comparator agents in patients with complicated skin and skin structure infections and complicated intra-abdominal infections and was approved for these indications in June 2005. The most common adverse events associated with tigecycline's administration during clinical trials were..

FDA approved moxifloxacin (Avelox, Schering-Plough) tablets and injection for the once-daily treatment of adults with complicated skin and skin structure infections (cSSSIs) caused by methicillin-susceptible Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, or Enterobacter cloacae.

Efficacy. The efficacy of ramelteon in the treatment of chronic insomnia was evaluated in 2 randomized, double-blind trials employing polysomnography (PSG).

Alvimopan (Entereg, Adolor/GlaxoSmithKline) for the treatment of postoperative ileus.

Discount prescription drug cards can help employees afford costly medication.

Entrepreneurial criminals actually are abandoning drug trafficking or more dangerous activities in favor of healthcare fraud.

August DTR Analysis.

DM continues to evolve with communication tools designed to meet shifting demands.

Comparison of the top 20 states by HMO enrollment in 2003 and 2004

As healthcare costs continue to spiral, the search for solutions is reaching a frantic pace. My experiences over the years have led me to believe that while Consumer- Directed Healthcare (CDHC) has entered the mainstream lexicon, it is far from understood.

There also needs to be sufficient access and guidance so the beneficiary can make informed and knowledgeable choices.

As a third grader, Jean Fraser thought she would become a doctor. Her science class dissected a chicken, and she became so fixated by the experience that she described the process in detail to her father during the family dinner each night. Unbeknown to her until recently, her descriptions back then had made her father sick to his stomach.

A review of agents in late-stage development for the treatment of selected genitourinary disorders (July 2005).

Cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely prescribed for patients with arthritis and other conditions because of their lower risk for gastrointestinal adverse events compared with nonselective NSAIDs 1,2

Dapoxetine (Alza/Ortho-McNeil) is a novel oral medication undergoing FDA review for premature ejaculation, one of the most common disorders of sexual dysfunction in men. Dapoxetine is a fast-acting inhibitor of the serotonin reuptake transporter. It has a short half-life and is structurally related to the antidepressant fluoxetine, allowing for on-demand dosing.

A study was conducted to determine the cost and patient adher- ence rates of lipid-lowering therapy with an extended-release niacin and lovastatin (ERNL) combination agent versus a separate extended-release niacin and statin (ERN-S) combination or statin monotherapy.

The objective of this study was to track the utilization of anti-inflammatory drugs among patients with active rofecoxib prescriptions at the time of market withdrawal through retrospective analysis of pharmacy records and to assess the need for COX-2 inhibitor therapy due to gastrointestinal risk factors.

Multiple condtions cause a ripple effect

HMO pharmacy copay comparison

There are more applications for handheld devices than just formulary compliance

Prescription bottle directions, medical jargon and varied interpretation can cause unintended health problems

July DTR Analysis

New payment methods clear a path for better management

Multiple condtions cause a ripple effect

The majority Of the funding for Medicaid comes from the federal government, while the administration for the program is performed largely by the states.

HMO pharmacy copay comparison

TUBERCULOSIS (TB), a chronic bacterial infection, is one of the world's oldest infectious diseases. It spreads through the air and usually infects the lungs, although other organs may also be involved.

Best practices indicate that health benefits are continued during employee and CEO transitions

In The Sprawling Surroundings of Oklahoma City sits a microcosm of what many stakeholders want for healthcare's future. The Oklahoma Heart Hospital, a 78-bed cardiac specialty hospital, offers the latest in high-tech medicine complemented by high-touch patient care.

A review of agents in late-stage development for the treatment of gastrointestinal disorders (June 2005).