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A bortezomib (Velcade)-based regimen significantly improved progression free survival (PFS) and consistently improved secondary efficacy end points in previously untreated mantle cell lymphoma (MCL) patients compared to standard therapy, according to data presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.

Ceritinib (Zykadia) previously known as LDK378,shrank tumors in patients with anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC), including those who had received previous treatment with an ALK inhibitor as well as patients receiving one for the first time, according to data presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago. Results were also observed in patients with ALK+ NSCLC who entered the study with brain metastases.

Patients across the country continue to feel the impact of critical prescription drug shortages. As formulary managers understand, an integrated approach to solving shortages, involving all supply chain stakeholders, can have a profound effect on mitigating the impact of shortages on patients.

When vaccines eradicate illnesses (eg, smallpox), life is grand. However, when eradication is impossible (eg, pneumococcus), what is the goal of vaccination? The most essential vaccine function is to reduce the number and/or severity of infections.

The Middle East respiratory syndrome (MERS) is an infectious viral disease with about 30% mortality caused by viral pneumonia and associated lung damage. The etiologic agent of MERS, MERS-CoV, is a member of the coronavirus family. Coronaviruses are responsible for a variety of pathologic effects in a broad spectrum of vertebrates including the virus currently responsible for epidemic piglet deaths in hog farms in the United States. The pathogenicity of MERS is due, in part, to the innate immune deficiency state that results from inhibition of a first responder to viral infection, interferon (IFN).