Seven-day, transdermal buprenorphine patches are as effective as sublingual buprenorphine in the treatment of patients with osteoarthritis pain, according to a randomized, double-blind clinical trial recently published on-line ahead of print in the Journal of Pain and Symptom Management.
Seven-day, transdermal buprenorphine patches are as effective as sublingual buprenorphine in the treatment of patients with osteoarthritis pain, according to a randomized, double-blind clinical trial recently published on-line ahead of print in the Journal of Pain and Symptom Management.
In this clinical trial, researchers randomized 246 patients (110 completed the study) between the ages of 18 and 80 with osteoarthritis pain in either the hip(s) and/or knee(s) to receive 7-day transdermal buprenorphine patches (5, 10, and 20 µg/hour) or sublingual buprenorphine (200-mg and 400-mg tablets). Both medications were titrated to pain control (over a 21-day period) and patients were treated for up to 7 weeks. The primary outcome measure of this study was pain intensity (as measured by Box Scale-11 [BS-11], where 0=no pain; 10=pain as bad as you can imagine) at day 28.
During the 28-day assessment period, the mean treatment differences in BS-11 scores were 0.00 (95% CI, –0.68 to 0.69), –0.11 (95% CI, –0.85 to 0.63), and –0.13 (95% CI, –0.95 to 0.68), for the morning, midday, and evening scores. All the confidence intervals were within the pre-specified limits (–1.5 to 1.5) suggesting equivalent pain control with buprenorphine patches and sublingual tablets. The use of escape medication was low.
In addition to equivalent efficacy, transdermal buprenorphine was found to have superior tolerability in this randomized trial. Significantly fewer patients receiving the transdermal buprenorphine patches reported nausea, dizziness and vomiting compared with the sublingual formulation (P<.039 for all).
David Calabrese of OptumRx Talks Top Three Drugs in Pipeline, Industry Trends in Q2
July 1st 2020In this week's episode of Tuning Into The C-Suite podcast, MHE's Briana Contreras chatted with David Calabrese, R.Ph, MHP, who is senior vice president and chief pharmacy officer of pharmacy care services company, OptumRx. David is also a member of Managed Healthcare Executives’ Editorial Advisory Board. During the discussion, he shared the OptumRx Quarter 2 Drug Pipeline Insights Report of 2020. Some of the information shared includes the three notable drugs currently being reviewed or those that have been recently approved by the FDA. Also discussed were any interesting industry trends to watch for.
Listen
FDA Sets Goal Date for Lymphoma Drug Columvi
December 5th 2024The combination of Columvi, gemcitabine and oxaliplatin is the first CD20xCD3 bispecific antibody to show positive results in a randomized diffuse large B-cell lymphoma phase 3 trial. The FDA’s decision is expected by July 20, 2025.
Read More