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Top 5 HIV Articles in 2023

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Article

This year's top HIV articles include one sharing data from a group of researchers from University of Pittsburgh who looked to see if T cell activation is sufficient to drive SIV disease progression.

  1. T Cell Activation Seen as Insufficient to Drive HIV Infection
    Chronic T cell immune activation and inflammation are key features of HIV-1 infection in humans and simian immunodeficiency virus (SIV) infection of rhesus macaques, and a group of researchers from University of Pittsburgh looked to see if T cell activation is sufficient to drive SIV disease progression.
    Read here
  2. Immune Checkpoint Inhibitors Study for People Living With HIV Shows Promising Results
    Researchers and clinicians have been wary of treating people living with HIV with Keytruda, Opdivo and other immune checkpoint inhibitors because removing an inhibitory step in the immune response was seen as risky for people with compromised immune systems.
    Read here
  3. HIV Stays Controlled in These Individuals Even After They Stop Treatment. Understanding Why Could Provide Clues to a ‘Functional Cure'
    A team of researchers studied 22 HIV 'post-treatment controllers' — people whose HIV infections are kept in check even after stopping antiretroviral therapy.
    Read here
  4. Advancing Options for Gene Editing for HIV-1
    CRISPR gene-editing therapy is predicted to cost about $1 million dollars per person which is considerably more expensive than keeping a patient on ART for the rest of their life.
    Read here
  5. On Long-Term Treatment, Piggybacking on Hepatitis C Eradication and the ‘Biggest Buzz' in HIV: A Conversation with Angel I. Ribó, PA-C, MPAS
    Ribó is the faculty advisor to new POCN Center for HIV Excellence that will provide information and resources to providers who may see relatively few patients with HIV.
    Read here
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