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Our July 2026 issue|

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Opinion|Videos|May 20, 2026

Takeaways from the phase 1/2 LINKER-MM4 and other ongoing trials of early-line bispecific antibody treatment

Author(s)C. Brooke Adams, Pharm.D., BCOP

LINKER-MM4 is an open-label study of linvoseltamab as monotherapy in patients who have been newly diagnosed with multiple myeloma. Adams said the results are showing “outstanding efficacy” of 95% that may be due to patients having healthier T cells while still in early-stage treatment.

Episodes in this series

EP. 1 An overview of the prevalence and treatment of multiple myeloma

EP. 1 An overview of the prevalence and treatment of multiple myeloma

EP. 2 What the introduction of bispecific antibodies has meant for the treatment of multiple myeloma

EP. 2 What the introduction of bispecific antibodies has meant for the treatment of multiple myeloma

EP. 3 Where bispecific antibodies currently fit into the treatment of multiple myeloma and the distinctions among the currently approved therapies

EP. 3 Where bispecific antibodies currently fit into the treatment of multiple myeloma and the distinctions among the currently approved therapies

EP. 4 Factors that influence bispecific antibodies’ placement on formularies

EP. 4 Factors that influence bispecific antibodies’ placement on formularies

EP. 5 The influence of NCCN guidelines

EP. 5 The influence of NCCN guidelines

EP. 6 Bispecific antibodies are moving to earlier lines of treatment

EP. 6 Bispecific antibodies are moving to earlier lines of treatment

EP. 7 Patients who would benefit from early-line treatment bispecific antibodies

EP. 7 Patients who would benefit from early-line treatment bispecific antibodies

EP. 8 Advantages of bispecific antibodies over triplet and quadruplet therapies

EP. 8 Advantages of bispecific antibodies over triplet and quadruplet therapies

EP. 9 Takeaways from the phase 1/2 LINKER-MM4 and other ongoing trials of early-line bispecific antibody treatment

EP. 9 Takeaways from the phase 1/2 LINKER-MM4 and other ongoing trials of early-line bispecific antibody treatment

EP. 10 The value and cost-effectiveness of bispecific antibodies

EP. 10 The value and cost-effectiveness of bispecific antibodies

EP. 11 Operational challenges for health systems and managing side effects

EP. 11 Operational challenges for health systems and managing side effects

EP. 12 Takeaways about bispecific antibodies

EP. 12 Takeaways about bispecific antibodies

EP. 13 The bispecific era in multiple myeloma — Future directions: Written recap

EP. 13 The bispecific era in multiple myeloma — Future directions: Written recap

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