Positive Results for Vyxeos in Combination With Other Drugs Reported at ASCO Meeting
Phase 1b results show manageable toxicities with Venclexta and Rydapt.
Vyxeos is a combination of two chemotherapy agents, daunorubicin and cytarabine, in a lipid carrier that is designed to home in on dividing the malignant, rapidly dividing myeloid cell that characterizes acute myeloid leukemia.
It makes for a more powerful chemotherapeutic agent: “As a result, you can deliver more drug to a cancer and less drug to the rest of the body and it creates a better safety profile,” says
Robert Iannone, M.D., executive vice president, research and development, chief medical officer at Jazz Pharmaceutical, the developer of Vyxeos.
Now researchers are testing with whether Vyxeos can be combined with other chemotherapy agents — a combination agent combined with other drugs. The three-arm, phase 1b V-FAST study is designed to test Vyxeos with three different drugs: Venclexta (venetoclax), a BCL-2 inhibitor; Rydapt (midostaurin), a FLT3-inhibitor; and Idhifa (ensaidenib), an IDH2 inhibitor.
Results from the V-FAST presented at the American Society of Clinical Oncology’s annual meeting this week show that patients can take the full doses of Venclexta and Rydapt with Vyxeos that is well tolerated, Iannone said in a video interview with Managed Healthcare Executive.® Enrollment in the “C arm” of the trial that involves Idhifa is ongoing.
Iannone says preliminary results from V-FAST also suggest the Vyxeos combinations are efficacious.
Duvelisib Shows Promise in Treating Relapsed/Refractory CLL/SLL: Insights from the DUO Trial
June 17th 2024The recent DUO trial, a global Phase III study, compared the efficacy and safety of duvelisib, an oral PI3K inhibitor, with ofatumumab, an anti-CD20 antibody, in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had previously undergone at least one therapy.
Read More
Using the 'Pathway' Approach to Shorten the Time Between Cancer Diagnosis and Treatment
November 16th 2022In this episode of Tuning In to the C-Suite, Briana Contreras, editor with Managed Healthcare Executive spoke with Dr. Yuri Fesko, oncologist and vice president of Medical Affairs at Quest Diagnostics. In the conversation, Dr. Fesko addressed the ongoing issue of long gaps of times between receiving a diagnosis for a type of cancer and finally getting the treatment for it. Dr. Fesko shared the benefits a number of sectors receive when treating patients sooner and the steps to get there.
Listen
Verastem Begins Submission for Ovarian Cancer Combination
May 24th 2024Verastem is studying the combination of avutometinib and defactinib to treat low-grade serous ovarian cancer in patients with KRAS-mutations. The company plans to complete the new drug application in the second half of this year.
Read More
