Important Takeaways for Patients, Providers and Payers

EP: 1.Background on PROs in Psoriatic Arthritis

EP: 2.Common Symptoms and Treatments in Psoriatic Arthritis

EP: 3.Treatment Selection for Psoriatic Arthritis

EP: 4.Key Differences in Inclusion Criteria Between BE OPTIMAL and BE COMPLETE

EP: 5.Baseline Characteristics and Alignment to Clinical Practice

EP: 6.Analyzing Pain and Fatigue Outcomes

EP: 7.Examining Additional PROs from BE COMPLETE and BE OPTIMAL

EP: 8.Economic Impact and Adverse Events Associated with Bimekizumab

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EP: 9.Important Takeaways for Patients, Providers and Payers

Despite significant therapeutic advances in psoriatic arthritis treatment, substantial unmet medical needs persist, with many patients failing to achieve treatment goals even with current options. Bimekizumab addresses this gap by providing a new medication and a novel mechanism of action through comprehensive IL-17A and IL-17F inhibition, distinguishing it from existing IL-17A-only inhibitors. The phenomenon of gradual or sudden efficacy loss affects virtually all psoriatic arthritis medications over time, necessitating additional therapeutic options with distinct mechanisms to maintain optimal disease control and address critical outcomes, including pain, fatigue, work productivity and physical function.

The comprehensive clinical trial data demonstrate bimekizumab’s effectiveness in achieving low disease activity or remission while providing meaningful improvements across multiple patient-reported outcome measures. This represents a welcome addition to the therapeutic armamentarium, offering clinicians and patients another effective tool for managing this complex multidomain disease. Patient feedback has been overwhelmingly positive, with many expressing heartfelt gratitude for minimized disease activity and improved long-term prospects for structural damage prevention, enhanced work capacity and improved family life quality with reduced pain and fatigue burden.

The broader healthcare implications extend to multiple stakeholders, with patients benefiting from reduced suffering and improved function, clinicians gaining additional tools to address patient needs meaningfully and payers potentially realizing economic benefits through improved societal productivity and reduced healthcare burden. Untreated or inadequately treated patients with psoriatic arthritis represent substantial healthcare network burdens, making investment in effective treatments economically justified through improved disease activity control. The data support the value proposition that paying for advanced biologic therapies yields beneficial returns through enhanced patient outcomes, reduced healthcare utilization, and improved societal economic contribution, creating a compelling case for treatment access and coverage decisions.