Efficacy and Safety of Intravenous Induction and Subcutaneous Maintenance Therapy with Guselkumab for Patients with Crohn’s Disease

Panelists discuss how maintaining patients on effective single therapies for Crohn’s disease is preferable to switching between different mechanisms of action, while addressing access challenges created by insurance step-therapy requirements and biosimilar policies that can interfere with optimal treatment selection.

Panelists discuss how the expanding treatment landscape for Crohn’s disease includes multiple mechanisms of action such as anti-tumor necrosis factor (TNF) agents, anti-integrin agents, interleukin inhibitors, and Janus kinase (JAK) inhibitors, with particular focus on guselkumab’s unique dual-acting mechanism as an IL-23 p19 inhibitor that also reduces CD64 expression on intestinal macrophages, although the clinical significance of this dual action compared with other p19 inhibitors remains to be fully determined.