
This segment explains the clinical significance of BRAF V600E–mutant NSCLC and highlights why early comprehensive genomic profiling is essential for identifying patients who benefit most from targeted BRAF/MEK inhibition.

This segment explains the clinical significance of BRAF V600E–mutant NSCLC and highlights why early comprehensive genomic profiling is essential for identifying patients who benefit most from targeted BRAF/MEK inhibition.

This segment introduces the PHAROS trial design and rationale, describing how its dual-cohort structure and long follow-up provide foundational evidence for encorafenib + binimetinib in this rare population.