Individualizing Treatment for Hemophilia A: A Key Approach in An Evolving Treatment Landscape

EP: 1.Managing hemophilia A in an evolving treatment landscape: payer considerations

EP: 2.Balancing Aspects That Influence Hemophilia A Treatment Decisions

EP: 3.Counseling Patients With Hemophilia A: Medication Storage and Administration Techniques

EP: 4.Fostering Hemophilia A Treatment Adherence: Empowering Patients With Essential Supplies and Tools

EP: 5.Navigating Challenges When Switching Therapies in Hemophilia A

EP: 6.Safeguarding Hemostasis and Adherence in Hemophilia A: Specialty Pharmacy Strategies

EP: 7.Optimizing Hemophilia A Medication Use: Insights From Specialty Pharmacy

EP: 8.Treatment of Hemophilia A: Evolution, Standard of Care, and Challenges

EP: 9.Recognizing Bleeds and Tailoring Treatment: Addressing Challenges in Treating Hemophilia A Across Disease Severity

EP: 10.Addressing Unique Issues in Pediatric and Older Adult Patients With Hemophilia A

EP: 11.Patient Considerations in Hemophilia A: Choosing Therapy, Navigating Lifestyle Changes, and Access to Care

EP: 12.Optimizing Lifelong Prophylaxis in Hemophilia A: Dose Monitoring, Pharmacokinetic Profiling, and Age-Related Adjustments

EP: 13.Managing Inhibitors in Hemophilia A: Treatment Strategies

EP: 14.Navigating Novel Hemophilia A Treatment Options: Patient Priorities and Considerations When Switching Therapies

EP: 15.Understanding Gene Therapy for Hemophilia A: Patient Candidacy, Challenges, and Uncertainties

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EP: 16.Individualizing Treatment for Hemophilia A: A Key Approach in An Evolving Treatment Landscape

Jonathan Roberts, MD: As the hemophilia landscape evolves, I think the individualization of hemophilia therapy becomes all the more important. I think, as I mentioned, the old paradigm of prophylaxis was infusing every other day or 3 times per week. It was a lot more cookie-cutter [approach], I would say. People would ascribe to that and didn’t really look at pharmacokinetic profiles that much because there wasn’t really an onus there. There wasn’t really a need to. And I think the community accepted the fact that breakthrough bleeding was inevitable. So you did your best to try to prevent as much as you could. And then as you’ve had an aging hemophilia population, we see that even a few joint bleeds, even 1 joint bleed has the potential to cause lifelong morbidity, and our mandate should be to prevent bleeds, period, in people who have bleeding disorders. So with all of the new options, as I mentioned, you know, factor VIII therapy and nonfactor therapies, gene therapies, the tools in the toolbox and the choices that patients and clinicians have to make is a lot more than it ever has been. So there’s a lot of education that needs to happen for both patients and clinicians to understand the nuances of each of these therapeutic options. They ultimately need to be comfortable with the knowns and unknowns about whatever option they choose and know how to manage bleeding when it occurs or trauma or surgery when it happens. So, I think, as I said, it’s an exciting time. There are lots of changes and developments, but I think it makes people like myself in the field and our mandate to advance the field through better clinical translational basic science research is certainly what I’m devoting the rest of my career to and I know many other colleagues are as well. But it really puts the onus on us to better understand how these therapies can enhance people’s lives with hemophilia.

Transcript edited for clarity.