Diagnosis and Pathophysiology of Vitiligo

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EP: 1.Diagnosis and Pathophysiology of Vitiligo

EP: 2.Managing Vitiligo on the Body and the Associated Comorbidities

EP: 3.Economic Impact of Vitiligo in the United States

EP: 4.Socioeconomic Impact of Vitiligo

EP: 5.Impact of Vitiligo on the Mental Health of Patients

EP: 6.Treatment Approaches for Patients With Vitiligo

EP: 7.Off-Label Treatments for Patients With Vitiligo

EP: 8.Use of Ruxolitinib in Vitiligo Treatment

EP: 9.Patient Considerations for Ruxolitinib in Vitiligo Treatment

EP: 10.Payers Perspective on Ruxolitinib in the Vitiligo Treatment Pathway

EP: 11.Vitiligo Treatment: Adverse Effects of Ruxolitinib

EP: 12.Achieving an Optimal Multidisciplinary Care Model in Vitiligo Treatment

EP: 13.Addressing Barriers to Medication Access for Vitiligo Therapies

EP: 14.Vitiligo Treatment Cost Considerations for Payers

EP: 15.Treatment Effects on Quality of Life in Patients With Vitiligo

EP: 16.Special Population Considerations for Patients With Vitiligo

EP: 17.Resources for Patients With Vitiligo

Dr. Heather Woolery-Lloyd:Hello and welcome to this Managed Healthcare Executive program, “Payer Perspectives and Vitiligo: Optimizing Patient Outcomes With Novel Therapeutic Approaches.” My name is Dr. Heather Woolery-Lloyd, director of the Skin of Color Division at the Dr. Phillip Frost Department of Dermatology, University of Miami School of Medicine (in Florida). Joining me today in this virtual discussion are Dr. Chesahna Kindred, founder of the Kindred Hair and Skin Center in Columbia, Maryland; Dr. Gary Owens, president of Gary Owens Associates, (in) Ocean View, Delaware; and Renata Block, a physician’s assistant at Advanced Dermatology and Aesthetic Medicine in Chicago, Illinois. Today, we are going to talk about several topics, including an overview of vitiligo, an evaluation of therapy options for vitiligo and payer perspectives for the management of vitiligo.... Let’s get started with this discussion. First, I’d like to start with (Dr. Kindred). How do you diagnose vitiligo in someone who presents to your practice with depigmentation?

Dr. Chesahna Kindred: The diagnosis of vitiligo, thankfully, is one of the more straightforward diseases. Usually, (it) does appear with white spots, but I always do a white Wood’s lamp, and that helps me to notice the accentuation or a bright glowing to the skin. One of the reasons is because sometimes you can’t see the vitiligo, and I want to appreciate all the lesions of vitiligo to make sure I have a good assessment of how advanced the disease may or may not be.

Dr. Heather Woolery-Lloyd: Yes, I definitely think Wood’s lamp is very helpful, especially in patients with lighter skin, where it may not be as obvious.

Dr. Chesahna Kindred:Yeah.

Dr. Heather Woolery-Lloyd: I want to talk a little bit more about the pathophysiology of vitiligo. Renata, we know that vitiligo is an autoimmune disease. Can you tell us a little bit more about the pathophysiology of vitiligo?

Renata Block: We can all agree that it’s an autoimmune disease. The question is whether the immune system is attacking the melanocytes or (whether) it an intrinsic deficit within the melanocytes. We know that genetic component, genetic history or genetics can play a big role (with regard) to vitiligo as well as areas of trauma. Or maybe people are using depigmentation agents. That can definitely throw them into the vitiligo, depigmentation on the skin. Other factors can be maybe thyroid disease, like a hypo- or hyperthyroid, or endocrine disorders like diabetes and even adrenal insufficiency such as Addison disease.

Dr. Heather Woolery-Lloyd: Yeah. It’s interesting. I agree that we know it’s autoimmune, and I try to explain to my patients that this is an autoimmune condition. The simplest way to explain it is that the immune system is attacking the melanocytes, and that’s such an easy way for patients to understand. But it is so multifactorial when we think about vitiligo. There are so many other factors that play a role.

Renata Block: Absolutely. What you said (with regard) to explaining that to the patient, it’s kind of like an aha moment. But when they hear the word “autoimmune,” they are taken aback and it’s our job then to clarify what exactly that means. It means that the immune system is (homing) in on those melanocytes. But again, is it (an) intrinsic deficit within the melanocytes? That’s what I would like to know.

Dr. Heather Woolery-Lloyd: Right. It’s very interesting. I like that idea of saying “(homing) in” because I think for patients that is a little more palatable than saying “autoimmune.” I think that can sometimes be a scary word.

Transcript edited for clarity.