New guidelines for atrial fibrillation management incorporate dabigatran
April 1st 2011An update on the management of atrial fibrillation issued by a task force consisting of the American College of Cardiology Foundation, the American Heart Association, and the Heart Rhythm Society has incorporated dabigatran into its recommendations.
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Metastatic breast cancer: A review of current and novel pharmacotherapy
April 1st 2011Despite advancements, treatment of metastatic breast cancer hinges on multifarious factors and numerous unanswered questions about therapy linger. Agents that are highly active in heavily pretreated patients are needed to optimize outcomes in patients with metastatic disease. This article reviews current and novel treatment options for metastatic breast cancer.
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New meta-analysis argues against a link between ARB use and increased cancer risk
March 25th 2011The use of angiotensin-receptor blockers alone are not associated with increased odds of cancer or cancer-related death, according to a meta-analysis published in a recent edition of Lancet Oncology.
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FDA, EMA announce pilot for parallel assessment of Quality by Design applications
March 25th 2011FDA and the European Medicines Agency have launched a new pilot program that will allow parallel evaluation of relevant development and manufacturing data components, known as Quality by Design, of new drug marketing applications that are submitted to both agencies.
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Resistance testing should guide initial treatment choice in HIV
March 18th 2011A substantial portion of antiretroviral-naïve patients are infected with transmitted drug-resistant HIV with one or more drug-resistant mutations, and they are much more likely to experience treatment failure, according to research published in The Lancet Infectious Diseases.
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Anti-tumor necrosis factor-α effective in psoriatic arthritis
March 18th 2011Patients with psoriatic arthritis undergoing their first treatment with tumor necrosis factor-? inhibitor showed a high adherence to therapy and a good response, according to a recent Danish study published in Arthritis & Rheumatism.
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Low literacy predicts nonadherence to medication regimens
March 18th 2011Many patients, especially those with limited literacy, do not consolidate prescription medication regimens efficiently, which could lead to nonadherence, according to a recent study in the Archives of Internal Medicine.
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Both benefits and adverse effects influence elderly's adherence to cardiovascular medication
March 18th 2011The willingness of the elderly to take medication for primary cardiovascular disease prevention is relatively insensitive to its benefit but highly sensitive to its adverse effects, according to a recent study published in the Archives of Internal Medicine.
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XLHealth optimistic about special needs plans
March 15th 2011XLHealth, a Baltimore-based provider of health plan solutions for Medicare beneficiaries with special needs, announced the enrollment of its 100,000th member, and it sees room for more growth despite expected Medicare Advantage cuts
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FDA: Monthly liver enzyme tests no longer needed for PAH drug
March 11th 2011FDA has approved a change to the prescribing information for ambrisentan 5-mg and 10-mg tablets (Letairis, Gilead Sciences) once-daily treatment to improve exercise ability and delay clinical worsening in patients with pulmonary arterial hypertension (PAH, WHO Group 1) and predominantly WHO Functional Class II-III symptoms.
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