News

First inhaled prostacyclin approved for pulmonary arterial hypertension

If approved, cilansetron (Calmactin, Solvay Pharmaceuticals) would be the second selective 5-HT3 antagonist introduced for the treatment of irritable bowel syndrome (IBS). Based on 2 main clinical trials, cilansetron 2 mg orally 3 times daily appears to be effective in the relief of IBS-D symptoms (abdominal pain/discomfort) and abnormal bowel habits in both male and female patients. Adverse effects were minor, with constipation being the most commonly reported adverse effect. No information is currently available on cilansetron's potential for drug interactions, need for dose adjustments in renal or hepatic insufficiency, long-term safety, or cost. Cilansetron was granted priority review status by FDA on September 1, 2004, for the treatment of diarrhea-predominant IBS in men and women. Currently marketed agents for the treatment of IBS are only approved for use in female patients.

Benign prostatic hyperplasia (BPH) is a common chronic disease, with the incidence of BPH increasing with age. Histopathologic features are present in almost half of all men aged >60 years. The disease can have a profoundly negative impact on patients' quality of life, often causing them to limit or avoid basic activities of daily living. Many patients who develop BPH will seek treatment for bothersome lower urinary tract symptoms (LUTS).

Medicaid: Top 20 States by Enrollment

Recent Acquisitions of companies specializing in consumer-driven health plans (CDHPs) may lead to further product innovation and competition in the managed care market.

Politics are a very strange animal. The vehemence brought to the table by the extreme left and right, and just about everyone in between, strikes me as both frightening and encouraging.

Medicaid enrollment is up in 18 of the top 20 states

At a minimum, healthcare organizations must show an ongoing effort to assess their level of compliance. And for many, compliance is uncharted territory where processes, costs and solutions are unknown.

From a compliance standpoint, one medical center wanted to make sure that none of its personal health information (PHI) was leaving the network.

Medicaid: Top 20 States by Enrollment

Paying physicians for performance is one of managed care's hottest trends.

New entities and actions in brief

Sexually Transmitted infections (STIs) such as syphilis, gonorrhea, herpes and chlamydia are a major health concern in the United States.

A possible hospice barrier is the requirement that patients forego further curative care.

As George Bernard Shaw once said, "Nothing is ever done in this world until men are prepared to kill one another if it is not done." While accidental fatalities, even those caused by preventable mistakes and human errors, are a far cry from murder, Don Berwick, MD, has seen enough death. He's also heard enough rhetoric about ways to improve healthcare quality.

The American Heart Association (AHA) Scientific Sessions comprise the largest meeting of its kind held in the cardiovascular field, with several thousand presentations given each year. The recently concluded 2004 AHA Scientific Sessions, which took place in New Orleans, included presentations of trials that evaluated potential therapeutic compounds, as well as widely used and accepted compounds in new dosages or combinations, for the treatment of cardiovascular disorders. The compilation of clinical news that follows focuses on the cardiovascular pharmacotherapy trials of greatest interest to formulary decision-makers, including: CREATE, PEACE, A-HeFT, PROTECT, CLEAR Platelets, DIPOM, GEMINI, SHIELD, and RIO-NA.

Secretary Tommy G. Thompson resigns, EPA administrator Michael Leavitt nominated replacement; HHS purchases 1.2 million doses of flu vaccine

A review of select agents in late-stage development for the treatment of arrhythmia, congestive/chronic heart failure, and pulmonary hypertension (PDF) (January 2005)

Serious infections due to the Aspergillus and Candida species and other filamentous fungi have emerged as an increasing cause of infectious morbidity and mortality in the United States and globally. The most notable explanation for this increase is a rise in the number of immunocompromised patients due to advances in transplantation, the emergence and prevalence of Acquired Immunodeficiency Syndrome (AIDS), and an increase in the number of invasive surgical procedures. 1-3 Treatment of these infections with currently available standard antifungal agents such as amphotericin B, itraconazole, and fluconazole still results in an unacceptably high associated mortality. 3. Furthermore, many of these antifungal agents have limitations, including dose-limiting toxicity, drug-drug interactions, and fungal resistance. 4-10

Transparency among PBMs continues to be an important strategy that should be approached openly.

Small business has its own distinct list of needs for health benefits.

California clinicians gather to share information for the benefit of all.

Jan. DTR Analysis: Successful PBMs establish trust

In early 2004, prestigious Oschner Clinic Foundation sold its 125,000-member health plan to Humana. The sale was the latest, most visible example of an industry trend.

Services offered by PBMs

Migraine headaches can be so painful that patients want to stay in a dark, quiet room until the pain subsides. They have a throbbing or pulsating quality, and they're often only on one side of the head.

HSAs are popular, but will they really change the economics of healthcare for the better?

SHORTLY AFTER the Allied victory in 1945, Albert Einstein produced one of his most-famous quotes: "I do not know what will be used in the next world war?assuming there will be another one?but the fourth world war will be fought with stones."An ominous statement from a truly brilliant man, to be sure. Hopefully, we'll never have to find out, but even if the next war is fought with clubs and rocks, there will still be a need for medical specialists to take care of the wounded.