Kimber Simmons, MD, MS, discusses how type 1 diabetes is a progressive autoimmune disease requiring early identification through autoantibody screening and C-peptide monitoring, with management approaches evolving from reactive insulin replacement toward proactive immunomodulation and beta cell preservation strategies that can alter disease trajectory and improve outcomes.
EP. 1: Type 1 Diabetes: Understanding Disease Progression and Beta Cell Function
March 28th 2025A panelist discusses how type 1 diabetes (T1D) is a complex autoimmune disease characterized by progressive beta cell destruction that advances through distinct stages, with genetic predisposition, environmental triggers and the presence of specific autoantibodies serving as key risk factors and diagnostic markers.
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EP. 2: C-Peptide and Early Type 1 Diabetes Detection
April 4th 2025A panelist discusses how C-peptide serves as a critical biomarker of endogenous insulin production, providing clinicians with valuable insights into remaining beta cell function that can guide personalized treatment approaches and help predict disease progression in patients with type 1 diabetes (T1D).
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EP. 3: Advancing Early Detection: Autoimmune Screening in Type 1 Diabetes
April 11th 2025A panelist discusses how autoimmune screening through detection of diabetes-specific autoantibodies serves as a critical tool for identifying pre-symptomatic type 1 diabetes (T1D), enabling earlier intervention before significant beta cell loss occurs and potentially changing the disease trajectory through timely management strategies.
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EP. 4: Misdiagnosis of Type 1 Diabetes in Adults: Prevalence, Causes and Consequences
April 18th 2025A panelist discusses how type 1 diabetes (T1D) is frequently misdiagnosed in adults due to its overlapping clinical features with type 2 diabetes (T2D), resulting in inappropriate treatment strategies that fail to address the autoimmune destruction of beta cells and lead to accelerated disease progression and complications.
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EP. 5: Preserving Beta Cell Function in T1D: Current Strategies and Emerging Therapies
April 25th 2025A panelist discusses how preserving beta-cell function in type 1 diabetes (T1D) requires a multifaceted approach combining timely diagnosis, immunomodulatory therapies, optimal glycemic control and emerging technologies that can slow disease progression and improve patient outcomes.
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