Bronchiectasis causes permanent dilation of the bronchial airways that leads to chronic mucus retention, inflammation, and infection, with exacerbations representing the disease's highest clinical and patient burden.
Targeting Neutrophilic Inflammation to Prevent Exacerbations in Bronchiectasis
Chronic neutrophilic inflammation, driven in part by neutrophil elastase, is strongly linked to exacerbation frequency in bronchiectasis, and current therapies offer little ability to target that inflammatory pathway directly.
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