Smokers look older than their nonsmoking counterparts and are at greater risk   of bladder cancer. Research published in 

 March 24 issue   found smokers to have higher levels of a skin protein that causes collagen,   which keeps skin firm and elastic, to degrade. In the April 4 issue of the 

Journal   of the National Cancer Institute

, a study found that smokers have a two   and a half times greater risk of bladder cancer than nonsmokers, and the risks   for women are higher than for men at most levels. 