FDA advisers recommend easing Avandia restrictions
July 25th 2013FDA advisers recommended in early June the easing of restrictions on the diabetes drug rosiglitazone (Avandia, GlaxoSmithKline), following an independent re-examination of GSK’s RECORD study conducted by Duke Clinical Research Institute.
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Telmisartan and valsartan present lower risk of heart attack and strokes in diabetes patients
July 24th 2013Telmisartan and valsartan, used to reduce blood pressure in people with diabetes, are associated with a lower risk of hospitalization for heart attack, stroke, or heart failure, according to a study published on the Canadian Medical Association Journal.
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Guideline adds aromatase inhibitor for breast cancer prevention
July 16th 2013The new update to the 2009 American Society of Clinical Oncology (ASCO) guideline on the pharmacologic interventions for breast cancer risk reduction now lists aromatase inhibitor exemestane (Aromasin, Pfizer) as an option for postmenopausal women for primary risk reduction that are at an increased risk of developing invasive breast cancer.
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Mobile app reminds patients to take their meds
July 15th 2013According to the World Health Organization, only 50% of patients living with a chronic illness take their medication on time as directed. An American dies every 19 minutes from skipping medication or taking meds incorrectly, costing US hospitals more than $100 billion every year.
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AREDS gets another look: Removing beta-carotene, adding lutein/zeaxanthin shows clear benefits
July 8th 2013Investigators had already determined that the Age-Related Eye Disease Study (AREDS) formulation slowed the progression to advanced age-related macular degeneration (AMD), with a 25% decrease in the likelihood of progression to advanced AMD compared with placebo.
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Underdosing in obesity-an epidemic: focus on antibiotics
July 4th 2013Obesity is associated with an increased risk of infection. Unfortunately clinical trials examining the safety and efficacy of antibiotics in obese patients are deficient. Thus, clinicians predominately rely on pharmacokinetic and pharmacodynamic data for appropriate antibiotic dosing. The current literature for vancomycin, aminoglycosides, beta-lactams, fluoroquinolones, linezolid, and macrolides was reviewed to evaluate appropriate dosing in obese patients. Due to the limited number of studies and various pharmacokinetic parameters of antibiotics, dosing should be based on both patient- and drug-specific factors.
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ICORE Healthcare-a subsidiary of Magellan Pharmacy Solutions-released the latest installment of its annual Medical Pharmacy & Oncology Trend Report.1 This report is unique in that it is the only trend and spend report that looks specifically at the medical benefit, under which almost half of all specialty pharmaceutical costs are currently managed and paid. Now in its third year, the report’s findings indicate that specialty pharmaceuticals are continuing to play an increasingly large role in managed care plan budgets and are certainly deserving of the increased payer attention they are receiving.
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Utilization management programs may increase appropriate use of medication and quality of healthcare
July 4th 2013Prime Therapeutics LLC (Prime) helps people get the medicine they need to feel better and live well. The company is headquartered in St. Paul, Minn., and manages pharmacy benefits for health plans, employers, and government programs including Medicare and Medicaid. The company processes claims and delivers medicine to nearly 20 million members, offering clinical services for people with complex medical conditions. Prime is collectively owned by 13 Blue Cross and Blue Shield Plans, subsidiaries or affiliates of those plans.
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In April 2013, FDA approved doxylamine succinate 10 mg, pyridoxine hydrochloride 10 mg (Diclegis, Duchesnay) for the treatment of nausea and vomiting in pregnant women who do not respond to conservative management. Diclegis is a delayed-release formulation combining 10 mg of the antihistamine doxylamine succinate and 10 mg of the vitamin B6 analog pyridoxine hydrochloride. This combination was once marketed in the United States as Bendectin. However, legal suits claiming related birth defects forced the manufacturer to withdraw Bendectin from the market in the 1980s. Doxylamine/pyridoxine has not been studied in women with hyperemesis gravidarum.
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Four-year update shows nilotinib induces significantly deeper molecular responses than imatinib
July 4th 2013The 4-year data from the landmark ENESTnd (Evaluating Nilotinib Efficacy and Safety in Clinical Trials – Newly Diagnosed Patients) trial continues to demonstrate the improved clinical benefit of front-line nilotinib (Tasigna) versus imatinib (Gleevec) in patients with newly diagnosed, Philadelphia chromosome-positive chronic myeloid leukemia (CML) in chronic phase
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