Patient access to orphan drugs faces new set of challenges
September 15th 2014In 1983, the United States enacted the Orphan Drug Act (ODA). An analogous law was passed in Europe in 2000. Both pieces of legislation are considered major successes in terms of spurring the development of orphan drugs. To illustrate, in the decade prior to 1983 only 34 orphan products were marketed, whereas in the past year alone 9 orphan drugs were launched. In the past 5 years, 39 orphan drugs were launched in the US across numerous therapeutic categories, including multiple myeloma, chronic myeloid leukemia, metastatic non-small cell lung cancer, hemophilia, tuberculosis, homozygous familial hypercholesterolemia, and cystic fibrosis.1
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Study: Patients with advanced dementia continue receiving inappropriate medications
September 11th 2014Nursing home residents with advanced dementia often receive medications of questionable benefit with costly consequences, according to a study published online September 8 in the Journal of the American Medical Association Internal Medicine.
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An investigational extended-release oral formulation of hydrocodone and acetaminophen the treatment of moderate to moderately severe acute pain was more effective than placebo at providing rapid and consistent pain relief in patients 48-hours post-surgery, according to a recent data presented at PAINWeek 2014 in Las Vegas.
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Experience Brief: Femoral nerve block reduces hospital admissions, opioids in pediatrics
September 10th 2014Nationwide Children’s Hospital is one of 13 medical centers nationwide participating in the Pediatric Regional Anesthesia Network, a collaboration designed to support the collection of highly audited data on practice patterns and complications and to facilitate collaborative research in regional anesthetic techniques in infants and children. Participating institutions report the number of regional anesthesia procedures they do each month. Researchers conducted this study at Nationwide Children’s Hospital in Columbus, Ohio, publishing its results in the Journal of Pediatric Orthopaedics in June.
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USPSTF recommends low-dose aspirin for women at high risk for preeclampsia
September 10th 2014The US Preventive Services Task Force (USPSTF) published a final recommendation statement recommending that women at high risk for preeclampsia use low-dose aspirin (81 mg/day) after 12 weeks of pregnancy to prevent the condition and its related health problems.
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Investigational heart failure drug cut cardiovascular deaths by 20% vs. ACE-inhibitor in study
September 5th 2014Patients with heart failure and reduced ejection fraction (HF-REF) treated with an investigational angiotensin receptor neprilysin Inhibitor (ARNI) are more likely to reduce cardiovascular death and heart failure hospitalization than those given ACE inhibitors or ARBs as first-line therapy in heart failure, according to data presented at the European Society of Cardiology congress in Barcelona, Spain, and published simultaneously in the New England Journal of Medicine.
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PerformRx, a member of the AmeriHealth Caritas family of companies, is a pharmacy benefits manager covering more than 3.5 million lives. In partnership with two affiliated Pennsylvania-based Medicaid managed care organizations (MCOs) ? a large Philadelphia-based Medical Assistance managed care health plan and AmeriHealth Caritas Pennsylvania-PerformRx implemented a collaborative drug therapy management (DTM) program for patients with diabetes treated with polypharmacy.
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FDA approves Promacta for use in patients with serious blood disorder
August 28th 2014FDA has approved a new indication for the once-daily use of eltrombopag (Promacta, GlaxoSmithKline) in patients with severe aplastic anaemia (SAA) who have had an insufficient response to immunosuppressive therapy (IST).
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Prescription at discharge linked to long-term adherence to stroke meds
August 28th 2014Stroke patients are 70% more likely to continue taking their stroke prevention medications 1 year later if they are given a prescription when discharged, and 40% more likely after 2 years, according a study published in the Journal of Stroke and Cerebrovascular Diseases.
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