Even before Trump’s oft-quoted sentiment that pharmaceutical manufacturers are “getting away with murder,” high drug prices have been in the national conversation. But renewed governmental interest (for instance, the recent Congressional hearing with heads of major drug manufacturers) has thrust the debate over drug costs—if they’re too high, why they’re so high, who’s shouldering the cost, who’s to blame—into an even brighter spotlight.
Various measurements for total drug spending show a growing problem: CMS estimates that between 2012 and 2016, drug spending increased 26.8%, while a recent PEW study found that net spending on drugs skyrocketed from $250.7 billion in 2012 to $341.0 billion in 2016—an increase of 36%.
But how are patients responding to these high prices? Evidence shows that while prescription abandonment due to cost is still relatively low, a not insignificant number of patients are either not initiating or are not filling current prescriptions—and many more are paying for their medications but struggling to do so.
The PEW study shows that manufacturer rebates also skyrocketed from 2012 to 2016 (from $39.7 billion to $89.5 billion) and that those rebates have played a role in at least partially offsetting those list prices. It also found that policies with capped out-of-pocket expenses, along with manufacturer cost-sharing policies, helped to shelter patients from rising costs.
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However, other reports show that patients are struggling under the weight of skyrocketing prices. One of the most recent larger-scale studies from GoodRx found that 42% of Americans struggle to pay for medications, even though the majority (94%) had some kind of health coverage. That same study found that around one-third of patients had purposely missed filling a prescription due to cost at least once in the last year—of that group, 5.6% said they had skipped prescriptions three or more times.
The CDC estimates from 2013, while lower, also paint a bleak picture: 7.8% of adults did not take their medication as prescribed in order to save money, while a further 1.6% bought their medications outside of the country and 4.2% used alternative therapies. A 2017 Truven Health Analytics-NPR Health Poll found that 29% of Americans had stopped taking medications at some point without telling their doctor. While side effects were the most common reason given for missing doses (29%), 10% cited cost as the reason.
The problem drugs
While it is challenging to find information on the most commonly abandoned medications, a 2010 study published in the Annals of Internal Medicine and created by collaboration between CVS, Harvard, and Brigham and Young Women’s Hospital, found that insulin and proton pump inhibitors (PPIs; examples include omeprazole or lansoprazole) were the most likely drugs to be abandoned. (Interestingly, opiates, anti-platelets, and statins were the least likely to be abandoned.)